Age- and type-specific hrHPV incidence estimates in screen-eligible women are relevant from a public health perspective because they provide an indication of the effect of vaccination on the occurrence of screen-positives in HPV-based screening. In this recent publication, the authors present age- and type-specific incidence estimates of screen-detected hrHPV from two large population-based screening trials (POBASCAM and NTCC). In the analyses hrHPV types are grouped according to their in- or exclusion in HPV vaccines. They report decreasing age trends of hrHPV vaccine and non-vaccine type incidences and age-related differences in the vaccine-type positivity among women with incident infections. Most importantly, hrHPV infections continued to be detected in all ages and the contribution of vaccine types remained substantial.
Veldhuijzen NJ, Berkhof J, Gillio-Tos A, et all The age distribution of type-specific high-risk human papillomavirus incidence in two population-based screening trials. Cancer Epidemiology and Biomarkers, Epub ahead of print
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